Regional anatomy of the pedunculopontine nucleus: relevance for deep brain stimulation.
Identifieur interne : 000809 ( Main/Exploration ); précédent : 000808; suivant : 000810Regional anatomy of the pedunculopontine nucleus: relevance for deep brain stimulation.
Auteurs : Marie-Pierre Fournier-Gosselin [Canada] ; Nir Lipsman ; Jean A. Saint-Cyr ; Clement Hamani ; Andres M. LozanoSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- anatomy & histology : Neural Pathways, Pedunculopontine Tegmental Nucleus.
- methods : Deep Brain Stimulation.
- physiology : Functional Laterality, Neural Pathways, Pedunculopontine Tegmental Nucleus.
- therapy : Parkinson Disease.
- Humans.
Abstract
The pedunculopontine nucleus (PPN) is currently being investigated as a potential deep brain stimulation target to improve gait and posture in Parkinson's disease. This review examines the complex anatomy of the PPN region and suggests a functional mapping of the surrounding nuclei and fiber tracts that may serve as a guide to a more accurate placement of electrodes while avoiding potentially adverse effects. The relationships of the PPN were examined in different human brain atlases. Schematic representations of those structures in the vicinity of the PPN were generated and correlated with their potential stimulation effects. By providing a functional map and representative schematics of the PPN region, we hope to optimize the placement of deep brain stimulation electrodes, thereby maximizing safety and clinical efficacy.
DOI: 10.1002/mds.25620
PubMed: 23926071
Affiliations:
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Le document en format XML
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<term>Neural Pathways (physiology)</term>
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<term>Pedunculopontine Tegmental Nucleus (physiology)</term>
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<front><div type="abstract" xml:lang="en">The pedunculopontine nucleus (PPN) is currently being investigated as a potential deep brain stimulation target to improve gait and posture in Parkinson's disease. This review examines the complex anatomy of the PPN region and suggests a functional mapping of the surrounding nuclei and fiber tracts that may serve as a guide to a more accurate placement of electrodes while avoiding potentially adverse effects. The relationships of the PPN were examined in different human brain atlases. Schematic representations of those structures in the vicinity of the PPN were generated and correlated with their potential stimulation effects. By providing a functional map and representative schematics of the PPN region, we hope to optimize the placement of deep brain stimulation electrodes, thereby maximizing safety and clinical efficacy.</div>
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<name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name>
<name sortKey="Saint Cyr, Jean A" sort="Saint Cyr, Jean A" uniqKey="Saint Cyr J" first="Jean A" last="Saint-Cyr">Jean A. Saint-Cyr</name>
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